Google 研究让 AI 智能体在湿实验室闭环完成适配体与蛋白设计
Google Research 公布三项研究,推进 AI 智能体从计算设计走向真实湿实验室实验:VERID 框架为实验室工作单元建立语义数字孪生,让智能体在动作前检查台面布局、孔内体积和吸头库存,并在模拟中预演协议。
入选理由:Google 展示了智能体在真实湿实验室中闭环设计并验证核酸适配体与蛋白结合体的进展,研究者可据此判断自动化实验的可行边界。
主题档案
能自主提出假设、做分析、跑实验的 AI 科学家与科研智能体,以及自动化实验室。
57 条精选近 30 天 28 条共收录 520 条
The Agentic Scientist: Orchestrating Coding Agents for Automated Scientific (Co-)Discovery Blog: https://pub.sakana.ai/agentic-scientist/ GitHub: https://github.com/SakanaAI/AI-Scientist-v3 arXiv: https://arxiv.org/abs/2610.18933 Since 2024, we’ve used The AI Scientist as a way to test how far AI alone can take scientific research, from v1 to v2 to the paper published in Nature earlier this year. The Agentic Scientist is the next step in that line of work, built for the era of coding agents. Coding agents such as Codex and Claude Code now carry out long software tasks on their own. Handing them a research problem, however, tends to produce a strong hyperparameter optimizer rather than a scientist: scores go up, but ideas stay narrow, and the reasons for the gain are rarely examined. The Agentic Scientist makes the research loop explicit. It wraps off-the-shelf coding agents in a scaffold that controls what they see, what they write, how they are evaluated, and how results are handed to the next stage. Parallel workers test hypotheses against rubrics defined before any experiment runs, share successes and failures through a common memory, and then ablate the winning program to generate evidence. We used an early version of the system to study Error Diffusion, a biologically motivated alternative to backpropagation. Our researchers set the question and the rubric, chose directions at each stage, and verified the results, references, and claims before submission. The resulting paper was accepted as an oral presentation at ALIFE 2026. In autonomous runs, the system also raised Doc-to-LoRA retrieval accuracy from 52% to 98% on multi-needle tasks and designed a learned evolution strategy that improves over its CMA-ES reference on unseen tasks. Alongside it we release AutoIllustrate, a pipeline for scientific figures that keeps an editable http://draw.io file as the source of truth, so every diagram can be corrected by hand. Humans define the question and the standards of evidence; agents expand the experiments researchers can run. We call this Co-Discovery, and we are releasing both systems as open source for the community to build on.
入选理由:Sakana AI 公开了把编码智能体组织成科研流程的开源框架,研究者可以据此判断人机分工的边界。
Google 发布智能体开发平台 Google Antigravity,提供面向生物学家的智能体科研工作台,把原本分散在多个数据库的检索压缩到一次会话中,并借助 ProtNLM 扫描 UniProt 中数百万条功能未知的蛋白质序列。
入选理由:Google 把跨数据库检索、结构分析与文献综合放进一个智能体会话,研究者可据此判断这类工作台能否压缩抗菌肽早期筛选流程。
在都柏林 AI in Science Summit 上,欧盟委员会启动 AI in Science Enablers Initiative,这是与 RAISE(Resource for AI Science in Europe)相连的共享框架,NVIDIA 宣布加入并提供加速工具、算力云资源、培训与技术支持、合作试点及初创生态支持。
入选理由:欧盟 RAISE 框架下 NVIDIA 开放模型、课程与算力通道,欧洲小型实验室和初创可据此判断能拿到哪些资源。
作者在 HuggingChat 中开启 ML-intern 模式,用提示词描述需求,由智能体完成规划、预算确认、小规模测试、训练、评估与发布,几天内做出六个公开模型,总 GPU 与 CPU 费用约 103 美元。
入选理由:作者用 ML Intern 在两天内自建六个小模型,公开了完整提示词与每项算力花费,研究者可据此评估智能体代跑训练流程的可行边界。
微软研究院开源 Agent Lightning v1.0,提出 Harnessed Agentic RL 训练范式,让部署时使用的智能体框架直接参与强化学习,无需在训练框架内重新实现智能体。
入选理由:微软研究院开源 Agent Lightning v1.0,让部署用的智能体框架直接参与强化学习训练,研究者可据此评估自建训练流水线的成本。
Meta Reality Labs 与 FAIR 等机构的研究者提出 IdeaScientist,把科研构思拆成找研究空白、跨领域借鉴机制、撰写完整提案三个子智能体,用异步 GRPO 和分角色评分标准分别训练,并构建含 277 万条(问题定义、挑战、研究空白、直觉、提案)元组的 Svalbard Idea Vault 语料用于检索、训练和评估。
编辑推荐理由:编辑推荐:直接服务科研构思与选题,作者已公开可运行框架代码和数据入口,研究者可自行部署验证。当前仍为预印本研究,效果主张来自作者评测。
Anthropic 研究博客发布客座文章,物理学家 Matthew Schwartz 描述他不再让 Claude 扮演人类科学家,而是寻找适合当前 LLM 能力的“Claude-shaped”问题,并为此构建开源工具包 BootLoops。
入选理由:一位物理学家复盘用 Claude 与 BootLoops 在 18 个领域推进 36 篇稿件的经验,对想找 AI 适配课题的研究者有参考价值。
Elicit 推出 Routines,用户用自然语言告诉 Elicit Research Agent 需要持续执行的任务,它就能按每日或每周的计划运行。Routines 在 Alerts 的基础上更进一步,不只提示有新论文,还会调查发生了什么变化并生成更新,例如每周一检索 CAR-T 疗法的新证据、更新摘要并说明改动及来源链接。
入选理由:Elicit 把文献监测从定期提醒扩展为可定时的检索与更新流程,研究者可据此判断能否替代每周重复的检索整理工作。